Potent,selective5-HT1Areceptorantagonist(IC50=15nM).Selectiveover5-HT1B,1C,2,α1,α2andD2receptors(IC50>1000nM).Centrallyactiveonsystemicadministration.
SoldwiththepermissionofWyeth-AyerstResearch,USPatent4,988,814
M.Wt | 468.47 |
Formula | C24H33N3O2.2HCl |
Storage | Desiccateat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 149007-54-5 |
PubChemID | 6604839 |
InChIKey | NYZFUZCCDOSQBG-AWEZNQCLSA-N |
Smiles | O=C(NC(C)(C)C)[C@@]([C@]3=CC=CC=C3)([H])CN(CC2)CCN2C1=C(OC)C=CC=C1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 46.85 | 100 | |
water | 2.34 | 5mMwithgentlewarming | |
water | 4.68 | 10mMwithsonication |
Thefollowingdataisbasedontheproductmolecularweight468.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.13mL | 10.67mL | 21.35mL |
5mM | 0.43mL | 2.13mL | 4.27mL |
10mM | 0.21mL | 1.07mL | 2.13mL |
50mM | 0.04mL | 0.21mL | 0.43mL |