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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/GW 4064/2473/10/10 mg
产品编号:2473/10
市  场 价:¥2780.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$139.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/GW 4064/2473/10/10 mg
商品介绍
Description:SelectivefarnesoidXreceptor(FXR)agoNIST
ChemicalName:3-[2-[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]ethenyl]benzoicacid
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selective,non-steroidalfarnesoidXreceptor(FXR)agonist(EC50=15nM).Displaysnoactivityatothernuclearreceptorsatconcentrationsupto1μM.Improveshyperglycaemiaandhyperlipidemiaindiabeticdb/dbmice.Showntosuppressautophagyinnutrient-deprivedmousehepatocytes.

LicensingInformation

SoldforresearchpurposesunderagreementfromGlaxoSmithKline

TechnicalData

M.Wt542.84
FormulaC28H22Cl3NO4
StorageDesiccateat+4°C
Purity≥97%(HPLC)
CASNumber278779-30-9
PubChemID9893571
InChIKeyBYTNEISLBIENSA-MDZDMXLPSA-N
SmilesCC(C)C1=C(COC2=CC(Cl)=C(C=CC3=CC=CC(=C3)C(O)=O)C=C2)C(=NO1)C1=C(Cl)C=CC=C1Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO54.3100
ethanol5.4310

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight542.84.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.84mL9.21mL18.42mL
5mM0.37mL1.84mL3.68mL
10mM0.18mL0.92mL1.84mL
50mM0.04mL0.18mL0.37mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet