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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/GW 3965 hydrochloride/2474/10/10 mg
产品编号:2474/10
市  场 价:¥4980.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$249.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/GW 3965 hydrochloride/2474/10/10 mg
商品介绍
Description:OrallyactiveliverXreceptor(LXR)agoNIST
ChemicalName:3-[3-[[[2-Chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]benzeneaceticacidhydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selective,orallyactivenon-steroidalagonistfortheliverXreceptor(LXR).Incell-basedreportergeneassays,actsasafullagonistofhLXRαandhLXRβ(EC50valuesare190and30nMrespectively).ReducesangiotensinII-mediatedincreasesinbloodpressure;up-regulatesABCA1geneexpressionandraisescirculatingHDLlevels.Displayspotentantiatherogenicactivityinmousemodelsofatherosclerosis.

LicensingInformation

SoldforresearchpurposesunderagreementfromGlaxoSmithKline

CompoundLibraries

GW3965hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt618.51
FormulaC33H31NO3ClF3.HCl
StorageDesiccateatRT
Purity≥98%(HPLC)
CASNumber405911-17-3
PubChemID16078973
InChIKeyNMPUWJFHNOUNQU-UHFFFAOYSA-N
SmilesCl.OC(=O)CC1=CC=CC(OCCCN(CC(C2=CC=CC=C2)C2=CC=CC=C2)CC2=C(Cl)C(=CC=C2)C(F)(F)F)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO61.85100
ethanol12.3720

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight618.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.62mL8.08mL16.17mL
5mM0.32mL1.62mL3.23mL
10mM0.16mL0.81mL1.62mL
50mM0.03mL0.16mL0.32mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet