Selective,orallyactivenon-steroidalagonistfortheliverXreceptor(LXR).Incell-basedreportergeneassays,actsasafullagonistofhLXRαandhLXRβ(EC50valuesare190and30nMrespectively).ReducesangiotensinII-mediatedincreasesinbloodpressure;up-regulatesABCA1geneexpressionandraisescirculatingHDLlevels.Displayspotentantiatherogenicactivityinmousemodelsofatherosclerosis.
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GW3965hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 618.51 |
Formula | C33H31NO3ClF3.HCl |
Storage | DesiccateatRT |
Purity | ≥98%(HPLC) |
CASNumber | 405911-17-3 |
PubChemID | 16078973 |
InChIKey | NMPUWJFHNOUNQU-UHFFFAOYSA-N |
Smiles | Cl.OC(=O)CC1=CC=CC(OCCCN(CC(C2=CC=CC=C2)C2=CC=CC=C2)CC2=C(Cl)C(=CC=C2)C(F)(F)F)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 61.85 | 100 | |
ethanol | 12.37 | 20 |
Thefollowingdataisbasedontheproductmolecularweight618.51.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.62mL | 8.08mL | 16.17mL |
5mM | 0.32mL | 1.62mL | 3.23mL |
10mM | 0.16mL | 0.81mL | 1.62mL |
50mM | 0.03mL | 0.16mL | 0.32mL |