Glucocorticoidreceptoragonist(pIC50=8).InhibitsproductionoftheproinflammatorymediatorIL-6invivo.
SoldforresearchpurposesunderagreementfromGlaxoSmithKline.
GSK9027isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 525.52 |
| Formula | C27H19F4N3O2S |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 1229096-88-1 |
| PubChemID | 24882669 |
| InChIKey | DXBJGDVBQPEMOB-UHFFFAOYSA-N |
| Smiles | FC(C=C3)=CC=C3N2C1=CC=C(C4=C(C(F)(F)F)C=C(NS(CC5=CC=CC=C5)(=O)=O)C=C4)C=C1C=N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 52.55 | 100 |
Thefollowingdataisbasedontheproductmolecularweight525.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.9mL | 9.51mL | 19.03mL |
| 5mM | 0.38mL | 1.9mL | 3.81mL |
| 10mM | 0.19mL | 0.95mL | 1.9mL |
| 50mM | 0.04mL | 0.19mL | 0.38mL |



