SelectiveRev-Erbαagonist(EC50=250nM).Enhancesrecruitmentofnuclearreceptorco-repressor(NCoR)peptidetoRev-Erbα;causesacutesuppressionofBMAl1genetranscription.InducesphaseshiftsinthecircADIanclock.
| M.Wt | 396.89 |
| Formula | C18H21ClN2O4S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1216744-19-2 |
| PubChemID | 50905018 |
| InChIKey | WYSLOKHVFKLWOU-UHFFFAOYSA-N |
| Smiles | CC(C)(C)OC(CN(CC2=CC=C(Cl)C=C2)CC1=CC=C([N+]([O-])=O)S1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.92 | 25 |
Thefollowingdataisbasedontheproductmolecularweight396.89.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.52mL | 12.6mL | 25.2mL |
| 5mM | 0.5mL | 2.52mL | 5.04mL |
| 10mM | 0.25mL | 1.26mL | 2.52mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |



