PotentandselectiveallostericinhibitorofWip1phosphatase(IC50=6nM).ExhibitsselectivityforWip1over21otherphosphatases.IncreasesphosphorylationofWip1substrates,includingp53,Chk2,H2AXandATM.Attenuatestumorcellgrowthinavarietyoflymphoidcelllines.Alsoinhibitslymphomaxenograftgrowthinvivo.Orallybioavailable.
SoldforresearchpurposesonlyunderagreementfromGlaxoSmithKline
GSK2830371isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 461.02 |
Formula | C23H29ClN4O2S |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 1404456-53-6 |
PubChemID | 70983932 |
InChIKey | IVDUVEGCMXCMSO-FQEVSTJZSA-N |
Smiles | ClC1=CC(NCC2=CC=C(C(N[C@H]([C@@](NC4CC4)=O)CC3CCCC3)=O)S2)=C(C)N=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 46.1 | 100 | |
ethanol | 23.05 | 50 |
Thefollowingdataisbasedontheproductmolecularweight461.02.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.17mL | 10.85mL | 21.69mL |
5mM | 0.43mL | 2.17mL | 4.34mL |
10mM | 0.22mL | 1.08mL | 2.17mL |
50mM | 0.04mL | 0.22mL | 0.43mL |