PotentandselectiveFFA4(GPR120)agonist(pEC50valuesare6.3,6.2and6.1atthehuman,mouseandratreceptor,respectively).Exhibits≥100-foldselectivityagainstapanelof61targetsincludingFFA1,FFA2andFFA3.Enhancesglucose-stimulatedinsulinsecretioninMIN6cells.InducesintracellularcalciumaccumulationinU2OScells;thisactivityisinhibitedbyAH7614(Cat.No.5256).
SoldforresearchpurposesunderagreementfromGlaxoSmithKline
GSK137647isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 305.39 |
Formula | C16H19NO3S |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 349085-82-1 |
PubChemID | 743974 |
InChIKey | FQUAFMNPXPXOJE-UHFFFAOYSA-N |
Smiles | CC1=CC(C)=CC(C)=C1NS(C2=CC=C(OC)C=C2)(=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 30.54 | 100 | |
ethanol | 15.27 | 50 |
Thefollowingdataisbasedontheproductmolecularweight305.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.27mL | 16.37mL | 32.75mL |
5mM | 0.65mL | 3.27mL | 6.55mL |
10mM | 0.33mL | 1.64mL | 3.27mL |
50mM | 0.07mL | 0.33mL | 0.65mL |