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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/GSK 137647/5257/10/10 mg
产品编号:5257/10
市  场 价:¥1980.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$99.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/GSK 137647/5257/10/10 mg
商品介绍
Description:PotentandselectiveFFA4(GPR120)agoNIST
ChemicalName:4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamide
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveFFA4(GPR120)agonist(pEC50valuesare6.3,6.2and6.1atthehuman,mouseandratreceptor,respectively).Exhibits≥100-foldselectivityagainstapanelof61targetsincludingFFA1,FFA2andFFA3.Enhancesglucose-stimulatedinsulinsecretioninMIN6cells.InducesintracellularcalciumaccumulationinU2OScells;thisactivityisinhibitedbyAH7614(Cat.No.5256).

LicensingInformation

SoldforresearchpurposesunderagreementfromGlaxoSmithKline

CompoundLibraries

GSK137647isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt305.39
FormulaC16H19NO3S
StorageStoreatRT
Purity≥99%(HPLC)
CASNumber349085-82-1
PubChemID743974
InChIKeyFQUAFMNPXPXOJE-UHFFFAOYSA-N
SmilesCC1=CC(C)=CC(C)=C1NS(C2=CC=C(OC)C=C2)(=O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO30.54100
ethanol15.2750

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight305.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.27mL16.37mL32.75mL
5mM0.65mL3.27mL6.55mL
10mM0.33mL1.64mL3.27mL
50mM0.07mL0.33mL0.65mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet