Smoothened(Smo)receptoragonist(EC50=1.2μM).Doesnotrecognizetheclassiccyclopamine(Cat.No.1623)bindingsite.DoesnotpromoteSmotranslocationtotheprimarycilium;isstronglypotentiatedbyforskolinandcholeratoxin.PromotesdifferentiationofmultipotentmesenchymalProgenitorcellsintoosteoblasts.
M.Wt | 450.53 |
Formula | C26H30N2O5 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 300833-95-8 |
PubChemID | 54683103 |
InChIKey | MDLUYYGRCGDKGL-UHFFFAOYSA-N |
Smiles | OC(C1=CC=CC=C1N2CCCCCC)=C(C(NC3=CC=C(C(OCCC)=O)C=C3)=O)C2=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 2.25 | 5mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight450.53.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.22mL | 11.1mL | 22.2mL |
5mM | 0.44mL | 2.22mL | 4.44mL |
10mM | 0.22mL | 1.11mL | 2.22mL |
50mM | 0.04mL | 0.22mL | 0.44mL |