PositiveallostericmodulatorofGABABreceptorfunction.PotentiatestheeffectsofGABAon[35S]GTPγSbindingatrecombinantandnativeGABABreceptors(EC50valuesare2.1and3.1μMrespectively).Decreasescocaineself-admiNISTration,blockstherewardingpropertiesofnicotineandproducesanxiolytic-likeactivitywithoutthesideeffectsassociatedwithbaclofenorbenzodiazepines.
M.Wt | 337.44 |
Formula | C15H23N5O2S |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 39069-52-8 |
PubChemID | 6604928 |
InChIKey | GSGVDKOCBKBMGG-UHFFFAOYSA-N |
Smiles | CSC1=NC(NC2CCCC2)=C(C(NC2CCCC2)=N1)[N+]([O-])=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 3.37 | 10 | |
ethanol | 1.69 | 5 |
Thefollowingdataisbasedontheproductmolecularweight337.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.96mL | 14.82mL | 29.63mL |
5mM | 0.59mL | 2.96mL | 5.93mL |
10mM | 0.3mL | 1.48mL | 2.96mL |
50mM | 0.06mL | 0.3mL | 0.59mL |