Selectivelysophosphatidicacid2(LPA2)receptornon-lipidagonist(EC50=3.3μM).DoesnotactivateotherLPAGPCRsatconcentrationsupto10μM.Antiapoptotic;inhibitsactivationofcaspases3,7,8and9,BaxtranslocationandPARP-1cleavage.ActivatesERK1/2survivalpathway.
M.Wt | 391.44 |
Formula | C22H17NO4S |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 325850-81-5 |
PubChemID | 3114900 |
InChIKey | GMVZUCHUOYUMLL-UHFFFAOYSA-N |
Smiles | O=C(C2=CC=CC3=CC=CC(C4=O)=C23)N4CCCSC1=CC=CC=C1C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 39.14 | 100 |
Thefollowingdataisbasedontheproductmolecularweight391.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.55mL | 12.77mL | 25.55mL |
5mM | 0.51mL | 2.55mL | 5.11mL |
10mM | 0.26mL | 1.28mL | 2.55mL |
50mM | 0.05mL | 0.26mL | 0.51mL |