Potentpan-Trkinhibitor.DisplaysantiproliferativeeffectsincellularBa/F3assays(IC50valuesare7,9and11nMforcellscontainingthefusionproteinsTel-TrkC,Tel-TrkBandTel-TrkA,respectively).ExhibitsselectivityforTrkreceptorsoverarangeofkinases,withsomeactivityatPDGFRandc-Kit(IC50valuesare0.87and0.91μMrespectively).Orallybioavailable.
GNF5837isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 535.49 |
Formula | C28H21F4N5O2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 1033769-28-6 |
PubChemID | 59397065 |
InChIKey | YYDUWLSETXNJJT-MTJSOVHGSA-N |
Smiles | O=C2NC1=CC(NC4=C(C)C=CC(NC(NC5=C(F)C=CC(C(F)(F)F)=C5)=O)=C4)=CC=C1/C2=C/C3=CC=CN3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 53.55 | 100 | |
ethanol | 5.35 | 10 |
Thefollowingdataisbasedontheproductmolecularweight535.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.87mL | 9.34mL | 18.67mL |
5mM | 0.37mL | 1.87mL | 3.73mL |
10mM | 0.19mL | 0.93mL | 1.87mL |
50mM | 0.04mL | 0.19mL | 0.37mL |