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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/GNF 5837/4559/10/10 mg
产品编号:4559/10
市  场 价:¥4900.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>激酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$245.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/GNF 5837/4559/10/10 mg
商品介绍
Description:PotentTrkinhibitor;inhibitsTrkA,TrkBandTrkC
ChemicalName:N-[3-[[2,3-Dihydro-2-oxo-3-(1H-pyrrol-2-ylmethylene)-1H-indol-6-yl]amino]-4-methylphenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentpan-Trkinhibitor.DisplaysantiproliferativeeffectsincellularBa/F3assays(IC50valuesare7,9and11nMforcellscontainingthefusionproteinsTel-TrkC,Tel-TrkBandTel-TrkA,respectively).ExhibitsselectivityforTrkreceptorsoverarangeofkinases,withsomeactivityatPDGFRandc-Kit(IC50valuesare0.87and0.91μMrespectively).Orallybioavailable.

CompoundLibraries

GNF5837isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt535.49
FormulaC28H21F4N5O2
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber1033769-28-6
PubChemID59397065
InChIKeyYYDUWLSETXNJJT-MTJSOVHGSA-N
SmilesO=C2NC1=CC(NC4=C(C)C=CC(NC(NC5=C(F)C=CC(C(F)(F)F)=C5)=O)=C4)=CC=C1/C2=C/C3=CC=CN3

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO53.55100
ethanol5.3510

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight535.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.87mL9.34mL18.67mL
5mM0.37mL1.87mL3.73mL
10mM0.19mL0.93mL1.87mL
50mM0.04mL0.19mL0.37mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet