PotentFFA2antagonist(IC50=9nM).ExhibitsselectivityforFFA2overFFA3.Inhibitsacetate-inducedhumanneutrophilmigrationinplasmaorbuffer.AlsoinhibitsFFA2-inducedexpressionofCD11bactivation-specificepitope(AE)inhumanwholeblood.Orallybioavailable.
| M.Wt | 485 |
| Formula | C25H25ClN2O4S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1391076-61-1 |
| PubChemID | 57520598 |
| InChIKey | MPMKMQHJHDHPBE-RUZDIDTESA-N |
| Smiles | O=C(N1[C@](C(N(CC2=CC(Cl)=CC=C2)CCCC(O)=O)=O)(C)CC1)C3=CSC4=C3C=CC=C4 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.NaOH | 9.7 | 20mMwithgentlewarming | |
| DMSO | 48.5 | 100 | |
| ethanol | 48.5 | 100 |
Thefollowingdataisbasedontheproductmolecularweight485.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.06mL | 10.31mL | 20.62mL |
| 5mM | 0.41mL | 2.06mL | 4.12mL |
| 10mM | 0.21mL | 1.03mL | 2.06mL |
| 50mM | 0.04mL | 0.21mL | 0.41mL |



