PotentFFA2antagonist(IC50=9nM).ExhibitsselectivityforFFA2overFFA3.Inhibitsacetate-inducedhumanneutrophilmigrationinplasmaorbuffer.AlsoinhibitsFFA2-inducedexpressionofCD11bactivation-specificepitope(AE)inhumanwholeblood.Orallybioavailable.
M.Wt | 485 |
Formula | C25H25ClN2O4S |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 1391076-61-1 |
PubChemID | 57520598 |
InChIKey | MPMKMQHJHDHPBE-RUZDIDTESA-N |
Smiles | O=C(N1[C@](C(N(CC2=CC(Cl)=CC=C2)CCCC(O)=O)=O)(C)CC1)C3=CSC4=C3C=CC=C4 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
1eq.NaOH | 9.7 | 20mMwithgentlewarming | |
DMSO | 48.5 | 100 | |
ethanol | 48.5 | 100 |
Thefollowingdataisbasedontheproductmolecularweight485.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.06mL | 10.31mL | 20.62mL |
5mM | 0.41mL | 2.06mL | 4.12mL |
10mM | 0.21mL | 1.03mL | 2.06mL |
50mM | 0.04mL | 0.21mL | 0.41mL |