Thyromimetic;highaffinityagonistatthyroidhormonereceptor(TR)βandTRαreceptors(KDvaluesare67and440pMrespectively).Displays5-and100-foldgreaterpotencythantheendogenousagonistT3invitroatTRα1andTRβ1receptorsrespectively.Promotesreversecholesteroltransportinchow-andfat-fedmice.Inducesproliferationofhepatocytesandpancreaticacinarcellsinratsindependentofpriortissueinjury.
GC1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 328.4 |
Formula | C20H24O4 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 211110-63-3 |
PubChemID | 9862248 |
InChIKey | QNAZTOHXCZPOSA-UHFFFAOYSA-N |
Smiles | CC1=CC(OCC(O)=O)=CC(C)=C1CC2=CC(C(C)C)=C(O)C=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 32.84 | 100 | |
ethanol | 32.84 | 100 |
Thefollowingdataisbasedontheproductmolecularweight328.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.05mL | 15.23mL | 30.45mL |
5mM | 0.61mL | 3.05mL | 6.09mL |
10mM | 0.3mL | 1.52mL | 3.05mL |
50mM | 0.06mL | 0.3mL | 0.61mL |