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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/GANT 61/3191/10/10 mg
产品编号:3191/10
市  场 价:¥3300.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$165.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/GANT 61/3191/10/10 mg
商品介绍
Description:GLIantagoNIST;inhibitsHedgehog(Hh)signaling
ChemicalName:2,2'-[[Dihydro-2-(4-pyridinyl)-1,3(2H,4H)-pyrimidinediyl]bis(methylene)]bis[N,N-dimethylbenzenamine
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

GLIantagonistthatinhibitsGLI1andGLI2-inducedtranscription(IC50~5μM).Inhibitsthehedgehog(Hh)signalingpathwaydownstreamofSMOandSUFUcausingGLI1nuclearaccumulation.Displaysantiproliferativeandantitumoractivityinvivo.InhibitsthepluripotencyfactorsOct4,Sox-2,Nanogandc-Mycinpancreaticcancerstemcells.

CompoundLibraries

GANT61isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt429.61
FormulaC27H35N5
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber500579-04-4
PubChemID421610
InChIKeyKVQOGDQTWWCZFX-UHFFFAOYSA-N
SmilesCN(C1=CC=CC=C1CN2CCCN(CC4=C(N(C)C)C=CC=C4)C2C3=CC=NC=C3)C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO21.4850
ethanol42.96100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight429.61.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.33mL11.64mL23.28mL
5mM0.47mL2.33mL4.66mL
10mM0.23mL1.16mL2.33mL
50mM0.05mL0.23mL0.47mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet