GLIantagonistthatinhibitsGLI1andGLI2-inducedtranscription(IC50~5μM).Inhibitsthehedgehog(Hh)signalingpathwaydownstreamofSMOandSUFUcausingGLI1nuclearaccumulation.Displaysantiproliferativeandantitumoractivityinvivo.InhibitsthepluripotencyfactorsOct4,Sox-2,Nanogandc-Mycinpancreaticcancerstemcells.
GANT61isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 429.61 |
Formula | C27H35N5 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 500579-04-4 |
PubChemID | 421610 |
InChIKey | KVQOGDQTWWCZFX-UHFFFAOYSA-N |
Smiles | CN(C1=CC=CC=C1CN2CCCN(CC4=C(N(C)C)C=CC=C4)C2C3=CC=NC=C3)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 21.48 | 50 | |
ethanol | 42.96 | 100 |
Thefollowingdataisbasedontheproductmolecularweight429.61.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.33mL | 11.64mL | 23.28mL |
5mM | 0.47mL | 2.33mL | 4.66mL |
10mM | 0.23mL | 1.16mL | 2.33mL |
50mM | 0.05mL | 0.23mL | 0.47mL |