GLIantagonistthatinhibitsGLI1-inducedtranscription(IC50=5μM).Inhibitsthehedgehog(Hh)signalingpathwaydownstreamofSMOandSUFUcausingGLI1nuclearaccumulation.Displaysantiproliferativeandantitumoractivityinvivo.
GANT58isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 392.48 |
Formula | C24H16N4S |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 64048-12-0 |
PubChemID | 253078 |
InChIKey | USWLOKMMUTWFMD-UHFFFAOYSA-N |
Smiles | C1(C5=CC=NC=C5)=C(C3=CC=NC=C3)C(C2=CC=NC=C2)=C(C4=CC=NC=C4)S1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 9.81 | 25 | |
ethanol | 9.81 | 25 |
Thefollowingdataisbasedontheproductmolecularweight392.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.55mL | 12.74mL | 25.48mL |
5mM | 0.51mL | 2.55mL | 5.1mL |
10mM | 0.25mL | 1.27mL | 2.55mL |
50mM | 0.05mL | 0.25mL | 0.51mL |