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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/GANT 58/3889/50/50 mg
产品编号:3889/50
市  场 价:¥13300.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$665.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/GANT 58/3889/50/50 mg
商品介绍
Description:GLI1antagoNIST;inhibitsHedgehog(Hh)signaling
ChemicalName:2,3,4,5-Tetra(4-pyridyl)thiophene
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

GLIantagonistthatinhibitsGLI1-inducedtranscription(IC50=5μM).Inhibitsthehedgehog(Hh)signalingpathwaydownstreamofSMOandSUFUcausingGLI1nuclearaccumulation.Displaysantiproliferativeandantitumoractivityinvivo.

CompoundLibraries

GANT58isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt392.48
FormulaC24H16N4S
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber64048-12-0
PubChemID253078
InChIKeyUSWLOKMMUTWFMD-UHFFFAOYSA-N
SmilesC1(C5=CC=NC=C5)=C(C3=CC=NC=C3)C(C2=CC=NC=C2)=C(C4=CC=NC=C4)S1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO9.8125
ethanol9.8125

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight392.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.55mL12.74mL25.48mL
5mM0.51mL2.55mL5.1mL
10mM0.25mL1.27mL2.55mL
50mM0.05mL0.25mL0.51mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet