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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/G-1/3577/10/10 mg
产品编号:3577/10
市  场 价:¥3780.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$189.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/G-1/3577/10/10 mg
商品介绍
Description:PotentandselectiveGPERagoNIST
ChemicalName:(±)-1-[(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]-ethanone
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveGPERagonist(Ki=11nM,EC50=2nM);displaysnoactivityatERαandERβatconcentrationsupto10μM.IncreasescytosolicCa2+andinhibitsmigrationofSKBr3cellsandMCF-7cellsinresponsetochemoattractants(IC50valuesare0.7and1.6nMrespectively)invitro.BlocksMCF-1cellcycleprogressionattheG1phase.DisplaystherapeuticeffectsinthemouseEAEmodelofmultiplesclerosis.

TechnicalData

M.Wt412.28
FormulaC21H18BrNO3
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber881639-98-1
PubChemID5322399
InChIKeyVHSVKVWHYFBIFJ-HKZYLEAXSA-N
SmilesCC(C5=CC([C@@]4([H])[C@@]([H])3CC=C4)=C(C=C5)N[C@H]3[C@]1=CC(OCO2)=C2C=C1Br)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO41.23100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight412.28.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.43mL12.13mL24.26mL
5mM0.49mL2.43mL4.85mL
10mM0.24mL1.21mL2.43mL
50mM0.05mL0.24mL0.49mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet