Selectiveinhibitoroferastininducedferroptosis(EC50=60nM).SpecificallyinhibitsRasselectivelethalcompound-induceddeath,butnotcelldeathinducedbyotheroxidativelethalcompoundsandapoptosis-inducingagents.Inhibitsferroptosisincancercells;alsoinhibitsglutamate-inducedcelldeathinorganotypicratbrainslices.Preventserastininducedaccumulationofcytosolicandlipidreactiveoxygenspecies.
Ferrostatin1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 262.35 |
Formula | C15H22N2O2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 347174-05-4 |
PubChemID | 4068248 |
InChIKey | UJHBVMHOBZBWMX-UHFFFAOYSA-N |
Smiles | O=C(OCC)C1=CC(N)=C(NC2CCCCC2)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 26.23 | 100 | |
ethanol | 26.23 | 100 |
Thefollowingdataisbasedontheproductmolecularweight262.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.81mL | 19.06mL | 38.12mL |
5mM | 0.76mL | 3.81mL | 7.62mL |
10mM | 0.38mL | 1.91mL | 3.81mL |
50mM | 0.08mL | 0.38mL | 0.76mL |