TLR2/6agonist(alsoaputativeTLR10ligand).ActivatesNF-κB.Inducespro-inflammatorycytokinesincludingIL-8,IL-1β,CCL20andTNF-αinvitro.SynergizeswithIFNγtoinduceCXCL10releasefrommelanomacells.
M.Wt | 1666.16 |
Formula | C84H140N14O18S |
Sequence | CGDPKHPKSF (Modifications:Cys=S-[2,3-Bis(palmitoyloxy)-(2-R/S)propyl]-Cys) |
Storage | Storeat-20°C |
CASNumber | 322455-70-9 |
PubChemID | 87858248 |
InChIKey | VJJLLNHELGKSNA-YWKNMTRCSA-N |
Smiles | CCCCCCCCCCCCCCCC(=O)OCC(CSC[C@@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)O)N)OC(=O)CCCCCCCCCCCCCCC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solubility | Solubleto2mg/mlinwater |
Thefollowingdataisbasedontheproductmolecularweight1666.16.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 0.6mL | 3mL | 6mL |
5mM | 0.12mL | 0.6mL | 1.2mL |
10mM | 0.06mL | 0.3mL | 0.6mL |
50mM | 0.01mL | 0.06mL | 0.12mL |