BindsspecificallyandwithhighaffinitytothepeptideDBIreceptor(benzodiazepinereceptor)onmitochondrialmembranes,inducingproductionofneurosteroids,whichmodulateGABAreceptors(EC50=3nMforincreaseinproductionofpregnenoloneinglialcells).Thusitreducesanxietywithoutcausingsedation.
FGIN-1-27isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 436.61 |
Formula | C28H37FN2O |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 142720-24-9 |
PubChemID | 132496 |
InChIKey | VUWXAQFLTSBUDB-UHFFFAOYSA-N |
Smiles | O=C(N(CCCCCC)CCCCCC)CC2=C(C3=CC=C(F)C=C3)NC1=CC=CC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 43.66 | 100 |
Thefollowingdataisbasedontheproductmolecularweight436.61.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.29mL | 11.45mL | 22.9mL |
5mM | 0.46mL | 2.29mL | 4.58mL |
10mM | 0.23mL | 1.15mL | 2.29mL |
50mM | 0.05mL | 0.23mL | 0.46mL |