IrreversIBLesteroidalaromataseinhibitor(IC50=20nM).DestABIlizesaromataseandlowersestrogenlevels;orallyactive.
SoldforresearchpurposesunderagreementfromPfizerInc.
ExemestaneisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 296.4 |
Formula | C20H24O2 |
Storage | Storeat-20°C |
Purity | ≥99%(HPLC) |
CASNumber | 107868-30-4 |
PubChemID | 60198 |
InChIKey | BFYIZQONLCFLEV-DAELLWKTSA-N |
Smiles | C[C@@]12C(C(C[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CCC4=O)=C)=CC(C=C1)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 29.64 | 100 | |
ethanol | 22.23 | 75 |
Thefollowingdataisbasedontheproductmolecularweight296.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.37mL | 16.87mL | 33.74mL |
5mM | 0.67mL | 3.37mL | 6.75mL |
10mM | 0.34mL | 1.69mL | 3.37mL |
50mM | 0.07mL | 0.34mL | 0.67mL |