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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Ex 26/5833/50/50 mg
产品编号:5833/50
市  场 价:¥13380.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$669.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Ex 26/5833/50/50 mg
商品介绍
Description:PotentandselectiveS1P1receptorantagoNIST
ChemicalName:1-[[[5'-[[1-(4-Chloro-3-methylphenyl)ethyl]amino]-2'-fluoro-3,5-dimethyl[1,1'-biphenyl]-4-yl]carbonyl]amino]-cyclopropanecarboxylicacid
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveS1P1receptorantagonist(IC50=0.93nM).Exhibits>3,000-foldselectivityforS1P1overS1P2,S1P3,S1P4andS1P5.InduceslymphocytesequestrationinperipherallymphnodesandupregulatesS1P1receptorexpression.ReducesdiseaseseverityinmicewithEAE.IncreasesIFN-αproductioninstimulateddendriticcellsinvivo.

CompoundLibraries

Ex26isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt494.98
FormulaC28H28ClFN2O3
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber1233332-37-0
PubChemID59393740
InChIKeyYVHNBORUVLWCKF-UHFFFAOYSA-N
SmilesCC(C1=CC(C)=C(C=C1)Cl)NC2=CC=C(C(C3=CC(C)=C(C(C)=C3)C(NC4(C(O)=O)CC4)=O)=C2)F

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO49.5100
ethanol49.5100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight494.98.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.02mL10.1mL20.2mL
5mM0.4mL2.02mL4.04mL
10mM0.2mL1.01mL2.02mL
50mM0.04mL0.2mL0.4mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet