MicrotubulestabilizationagentthatpromotestubulinpolymerizationandinducesG2-Mcellcyclearrest(EC50=32nMinHeLacells).Inhibitsproliferationofhumancarcinomacelllinesinvitro,includingMDRcellsoverexpressingtheP-glycoproteineffluxpump.ExhibitspotentcytotoxicityinMCF-7andA549cells(EC50valuesare0.3and2.7nMrespectively).InhibitsgrowthofHCT-15tumorsinmiceinvivo.
M.Wt | 507.68 |
Formula | C27H41NO6S |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 152044-54-7 |
PubChemID | 448013 |
InChIKey | QXRSDHAAWVKZLJ-PVYNADRNSA-N |
Smiles | CC1=NC(/C=[C@](C)/[C@@H](OC2=O)C[C@H]3[C@@](O3)(C)CCC[C@H](C)[C@H](O)[C@H](C([C@@](C)(C)[C@@H](O)C2)=O)C)=CS1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 5.08 | 10 |
Thefollowingdataisbasedontheproductmolecularweight507.68.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.97mL | 9.85mL | 19.7mL |
5mM | 0.39mL | 1.97mL | 3.94mL |
10mM | 0.2mL | 0.98mL | 1.97mL |
50mM | 0.04mL | 0.2mL | 0.39mL |