Selectivemineralocorticoid(aldosterone)receptorantagonist(IC50=360nM).Displays>27-foldselectivityoverandrogen,progesteroneandestrogenreceptors(IC50>10μM).Orallyactiveantihypertensiveinvivo.
M.Wt | 414.5 |
Formula | C24H30O6 |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 107724-20-9 |
PubChemID | 443872 |
InChIKey | JUKPWJGBANNWMW-VWBFHTRKSA-N |
Smiles | O=C1CC[C@@]2(C)C(C[C@@H]([C@](OC)=O)[C@]3([H])[C@@](O6)2[C@H]6C[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 4.14 | 10 |
Thefollowingdataisbasedontheproductmolecularweight414.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.41mL | 12.06mL | 24.13mL |
5mM | 0.48mL | 2.41mL | 4.83mL |
10mM | 0.24mL | 1.21mL | 2.41mL |
50mM | 0.05mL | 0.24mL | 0.48mL |