Cell-permeable,non-peptideinhibitorofX-linkedinhibitorofapoptosis(XIAP)(IC50=4.1μMincompetitionbindingassaywithSmacpeptide);bindstotheBIR3domain,preventingXIAPinteractionwithcaspase-9andSmac.Inhibitscellgrowth,inducesapoptosisandactivatescaspase-9inprostatecancercells(IC504-6μM),buthasaweakereffectonnormalprostatecells(IC50=19-20μM).OvercomestheprotectiveeffectofXIAPonapoptosisinXIAP-transfectedJurkatcells.Anti-tumor,analgesicandanti-inflammatoryinvivo.
M.Wt | 294.39 |
Formula | C17H26O4 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 550-24-3 |
PubChemID | 3218 |
InChIKey | IRSFLDGTOHBADP-UHFFFAOYSA-N |
Smiles | OC=1C(=O)C(CCCCCCCCCCC)=C(C(=O)C1)O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 29.44 | 100 | |
ethanol | 2.94 | 10mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight294.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.4mL | 16.98mL | 33.97mL |
5mM | 0.68mL | 3.4mL | 6.79mL |
10mM | 0.34mL | 1.7mL | 3.4mL |
50mM | 0.07mL | 0.34mL | 0.68mL |