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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Embelin/2156/10/10 mg
产品编号:2156/10
市  场 价:¥2380.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$119.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Embelin/2156/10/10 mg
商品介绍
Description:InhibitorofX-linkedinhibitorofapoptosis(XIAP);cell-permeableandantitumor
ChemicalName:2,5-Dihydroxy-3-undecyl-2,5-cyclohexADIene-1,4-dione
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Cell-permeable,non-peptideinhibitorofX-linkedinhibitorofapoptosis(XIAP)(IC50=4.1μMincompetitionbindingassaywithSmacpeptide);bindstotheBIR3domain,preventingXIAPinteractionwithcaspase-9andSmac.Inhibitscellgrowth,inducesapoptosisandactivatescaspase-9inprostatecancercells(IC504-6μM),buthasaweakereffectonnormalprostatecells(IC50=19-20μM).OvercomestheprotectiveeffectofXIAPonapoptosisinXIAP-transfectedJurkatcells.Anti-tumor,analgesicandanti-inflammatoryinvivo.

TechnicalData

M.Wt294.39
FormulaC17H26O4
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber550-24-3
PubChemID3218
InChIKeyIRSFLDGTOHBADP-UHFFFAOYSA-N
SmilesOC=1C(=O)C(CCCCCCCCCCC)=C(C(=O)C1)O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO29.44100
ethanol2.9410mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight294.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.4mL16.98mL33.97mL
5mM0.68mL3.4mL6.79mL
10mM0.34mL1.7mL3.4mL
50mM0.07mL0.34mL0.68mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet