P-glycoprotein(P-gp/ABCG1)inhibitor.BlocksP-gp-mediatedmultidrugresistance(MDR)ofthecytotoxicdrugsdoxorubicin(Cat.No.2252)andvincristine(Cat.No.1257)inCHRC5cells.Alsoinhibitsbreastcancerresistanceprotein(BCRP/ABCG2).Orallyactive.
SoldforresearchpurposesunderagreementfromGlaxoSmithKline.
| M.Wt | 600.1 |
| Formula | C34H33N3O5.HCl |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 143851-98-3 |
| PubChemID | 170320 |
| InChIKey | IQOJZZHRYSSFJM-UHFFFAOYSA-N |
| Smiles | O=C1C3=C(C(C(NC4=CC=C(CCN5CC(C=C(OC)C(OC)=C6)=C6CC5)C=C4)=O)=CC=C3)NC2=C1C=CC=C2OC.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 12 | 20 |
Thefollowingdataisbasedontheproductmolecularweight600.1.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.67mL | 8.33mL | 16.66mL |
| 5mM | 0.33mL | 1.67mL | 3.33mL |
| 10mM | 0.17mL | 0.83mL | 1.67mL |
| 50mM | 0.03mL | 0.17mL | 0.33mL |



