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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Eeyarestatin I/3922/10/10 mg
产品编号:3922/10
市  场 价:¥4100.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$205.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Eeyarestatin I/3922/10/10 mg
商品介绍
Description:PotentinhibitorofER-associatedproteindegradationandtranslocation
ChemicalName:3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentinhibitorofendoplasmicreticulumassociatedproteindegradation(ERAD).Specificallytargetsthep97-associateddeubiquinatingprocess(PAD)andinhibitsataxin-3(atx3)-dependentdeubiquitination.AlsoinhibitsSec61-mediatedproteintranslocationattheER.Displayscytotoxicactivitypreferentiallyagainstcancercells;inducescelldeathviatheproapoptoticproteinNOXA.

TechnicalData

M.Wt630.44
FormulaC27H25Cl2N7O7
StorageDesiccateat+4°C
Purity≥98%(HPLC)
CASNumber412960-54-4
PubChemID23947580
InChIKeyJTUXTPWYZXWOIB-LWWHHIEBSA-N
SmilesO=C1N(C2=CC=C(Cl)C=C2)C(N(O)C(NC4=CC=C(Cl)C=C4)=O)C(C)(C)N1CC(N/N=C/C=C/C3=CC=C([N+]([O-])=O)O3)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO63.04100
ethanol3.155mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight630.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.59mL7.93mL15.86mL
5mM0.32mL1.59mL3.17mL
10mM0.16mL0.79mL1.59mL
50mM0.03mL0.16mL0.32mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet