Potentinhibitorofendoplasmicreticulumassociatedproteindegradation(ERAD).Specificallytargetsthep97-associateddeubiquinatingprocess(PAD)andinhibitsataxin-3(atx3)-dependentdeubiquitination.AlsoinhibitsSec61-mediatedproteintranslocationattheER.Displayscytotoxicactivitypreferentiallyagainstcancercells;inducescelldeathviatheproapoptoticproteinNOXA.
M.Wt | 630.44 |
Formula | C27H25Cl2N7O7 |
Storage | Desiccateat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 412960-54-4 |
PubChemID | 23947580 |
InChIKey | JTUXTPWYZXWOIB-LWWHHIEBSA-N |
Smiles | O=C1N(C2=CC=C(Cl)C=C2)C(N(O)C(NC4=CC=C(Cl)C=C4)=O)C(C)(C)N1CC(N/N=C/C=C/C3=CC=C([N+]([O-])=O)O3)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 63.04 | 100 | |
ethanol | 3.15 | 5mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight630.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.59mL | 7.93mL | 15.86mL |
5mM | 0.32mL | 1.59mL | 3.17mL |
10mM | 0.16mL | 0.79mL | 1.59mL |
50mM | 0.03mL | 0.16mL | 0.32mL |