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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Echistatin, α1 isoform/3202/100U/100 ug
产品编号:3202/100U
市  场 价:¥6380.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$319.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Echistatin, α1 isoform/3202/100U/100 ug
商品介绍
Description:αVβ3andglycoproteinIIb/IIIa(integrinαIIbβ3)inhibitor
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentirreversIBLeαVβ3integrinantagoNIST(Ki=0.27nM).Disruptsattachmentofosteoclaststoboneandinhibitsbonereabsorption(IC50=0.1nM).PreventsADP-inducedplateletaggregationviainhibitionofglycoproteinIIb/IIIa(GpIIb/IIIa,αIIbβ3)receptors(IC50=30nM)invitro.

TechnicalData

M.Wt5417.1
FormulaC217H341N71O74S9
SequenceECESGPCCRNCKFLKEGTICKRARGDDMDDYCNGKTCDCPRNPHKGPAT

(Modifications:Disulfidebridgebetween2-11,7-32,8-37,20-39)

StorageStoreat-20°C
CASNumber154303-05-6
PubChemID90488810
InChIKeyKZMZKUVIDVBQGX-UHFFFAOYSA-N
Smiles[H]N[C@@H](CCC(O)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CSSC[C@@H]4NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H]5CCCN5C(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC1=O)C(=O)N3)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CC(O)=O)NC4=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CCCCN)NC2=O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolubilitySolubleto1mg/mlinwater

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight5417.1.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM0.18mL0.92mL1.85mL
5mM0.04mL0.18mL0.37mL
10mM0.02mL0.09mL0.18mL
50mM0mL0.02mL0.04mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet