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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/EPPTB/4518/10/10 mg
产品编号:4518/10
市  场 价:¥2980.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$149.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/EPPTB/4518/10/10 mg
商品介绍
Description:Traceamine1(TA1)receptorantagoNIST/inverseagonist
ChemicalName:N-(3-Ethoxyphenyl)-4-(1-pyrrolidinyl)-3-(trifluoromethyl)benzamide
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Traceamine1(TA1)receptorantagonist/inverseagonist;exhibitsahigherpotencyatthemouseTA1receptorthantheratandhumanTA1receptors(IC50valuesare27.5,4539and7487nM,respectively).BlockstheTA1receptor-mediatedactivationofaninwardlyrectifyingK+current,whichincreasesthefiringfrequencyofdopamine(DA)neuronsintheventraltegmentalarea.IncreasesDApotencyattheD2receptor.Alsodisplaysinverseagonism,reducingbasalcAMPlevelsinvitro(IC50=19nM).

CompoundLibraries

EPPTBisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt378.39
FormulaC20H21F3N2O2
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber1110781-88-8
PubChemID25175634
InChIKeyKLFVWQCQUXXLOU-UHFFFAOYSA-N
SmilesO=C(NC3=CC(OCC)=CC=C3)C1=CC(C(F)(F)F)=C(N2CCCC2)C=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO37.84100
ethanol37.84100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight378.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.64mL13.21mL26.43mL
5mM0.53mL2.64mL5.29mL
10mM0.26mL1.32mL2.64mL
50mM0.05mL0.26mL0.53mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet