请使用支持JavaScript的浏览器!
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/EHT 1864/3872/50/50 mg
产品编号:3872/50
市  场 价:¥17580.00
场      地:美国(厂家直采)
产品分类: 蛋白类>天然蛋白>球蛋白>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$879.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/EHT 1864/3872/50/50 mg
商品介绍
Description:PotentinhibitorofRacfamilyGTPases
ChemicalName:5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-onedihydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofRacfamilyGTPases.BlocksactivationbydirectbindingtoRac1,Rac1b,Rac2andRac3(KDvaluesare40,50,60and250nMrespectively).InhibitsRac,RasandTiam-inducedgrowthtransformationofNIH-3T3fibroblasts.Reducesβ-amyloidpeptideproductioninvivo.

LicensingInformation

SoldforresearchuseonlyunderlicensefromExonHitTherapeuticsS.A.

TechnicalData

M.Wt581.47
FormulaC25H27F3N2O4S.2HCl
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber754240-09-0
PubChemID9938202
InChIKeyLSECOAJFCKFQJG-UHFFFAOYSA-N
SmilesO=C1C=C(CN4CCOCC4)OC=C1OCCCCCSC3=CC=NC2=CC(C(F)(F)F)=CC=C23.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO43.6175
water58.15100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight581.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.72mL8.6mL17.2mL
5mM0.34mL1.72mL3.44mL
10mM0.17mL0.86mL1.72mL
50mM0.03mL0.17mL0.34mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet