Tubulinpolymerizationinhibitor.NoncompetitivelyinhibitsbindingofrADIolabeledvincristinetotubulin(Ki=1.4μM)andinducestubulinaggregationinvitro.
M.Wt | 899.11 |
Formula | C42H68N6O6S.CF3CO2H |
Storage | Storeat-20°C |
Purity | ≥95%(HPLC) |
PubChemID | 9810929 |
InChIKey | OFDNQWIFNXBECV-VFSYNPLYSA-N |
Smiles | O=C(C[C@@H](OC)[C@@H](N(C)C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)[C@@H](C)CC)N1[C@@]([C@H](OC)[C@@H](C)C(N[C@@H](CC3=CC=CC=C3)C2=NC=CS2)=O)([H])CCC1.FC(C(O)=O)(F)F |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solubility | SolubleinDMSO |
Thefollowingdataisbasedontheproductmolecularweight899.11.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.11mL | 5.56mL | 11.12mL |
5mM | 0.22mL | 1.11mL | 2.22mL |
10mM | 0.11mL | 0.56mL | 1.11mL |
50mM | 0.02mL | 0.11mL | 0.22mL |