TopoisomeraseIIinhibitorandintracellularionchelator.BridgesandstABIlizesaninterfacebetweentwoATPasepromoterstoinhibittopoisomeraseIIactivity.Cardioprotectivewhenco-admiNISTeredwithdoxorubicin;decreasesformationofreactiveoxygenspecies(ROS)andactivatesthePI3K/Aktsurvivalpathway.
| M.Wt | 304.73 |
| Formula | C11H16N4O4.HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 1263283-43-7 |
| PubChemID | 6918223 |
| InChIKey | BIFMNMPSIYHKDN-FJXQXJEOSA-N |
| Smiles | C[C@@H](CN2CC(NC(C2)=O)=O)N(CC(N1)=O)CC1=O.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.47 | 100 | |
| water | 30.47 | 100 |
Thefollowingdataisbasedontheproductmolecularweight304.73.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.28mL | 16.41mL | 32.82mL |
| 5mM | 0.66mL | 3.28mL | 6.56mL |
| 10mM | 0.33mL | 1.64mL | 3.28mL |
| 50mM | 0.07mL | 0.33mL | 0.66mL |



