Anticancerandantiviralagent;chemopreventiveandpro-apoptotic.Inhibitsphorbolester-inducedornithinedecarboxylaseandNADH:ubiquinoneoxidoreductaseactivities(IC50valuesare11and6.9nMrespectively).InhibitsPI3-kinaseandreducespAktlevelsinpre-malignantandmalignanthumanbronchialepithelialcells.Activeinvivo.
M.Wt | 394.42 |
Formula | C23H22O6 |
Storage | Storeat-20°C |
Purity | ≥97%(HPLC) |
CASNumber | 522-17-8 |
PubChemID | 107935 |
InChIKey | ORDAZKGHSNRHTD-UXHICEINSA-N |
Smiles | O=C(C(C=CC5=C4C=CC(C)(C)O5)=C4O3)[C@@]([C@@]3([H])CO2)([H])C1=C2C=C(OC)C(OC)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 39.44 | 100 | |
ethanol | 19.72 | 50 |
Thefollowingdataisbasedontheproductmolecularweight394.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.54mL | 12.68mL | 25.35mL |
5mM | 0.51mL | 2.54mL | 5.07mL |
10mM | 0.25mL | 1.27mL | 2.54mL |
50mM | 0.05mL | 0.25mL | 0.51mL |