PotentTLR7agonist(EC50=7.2nM).Activatesseveralimmuneeffectorcellsinvitro.SuppressesmetastasisinvivoandenhancesefficacyofrADIationtherapyinamodelofcolorectalcarcinoma.
DSR6434isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 400.48 |
Formula | C19H28N8O2 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 1059070-10-8 |
PubChemID | 25071151 |
InChIKey | SSZHESNDOMBSRV-UHFFFAOYSA-N |
Smiles | O=C2N(CC3=CC=C(OCCN(C)C)N=C3)C1=NC(NCCCC)=NC(N)=C1N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
1eq.HCl | 20.02 | 50 | |
DMSO | 40.05 | 100 |
Thefollowingdataisbasedontheproductmolecularweight400.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.5mL | 12.49mL | 24.97mL |
5mM | 0.5mL | 2.5mL | 4.99mL |
10mM | 0.25mL | 1.25mL | 2.5mL |
50mM | 0.05mL | 0.25mL | 0.5mL |