PotentTLR7agonist(EC50=7.2nM).Activatesseveralimmuneeffectorcellsinvitro.SuppressesmetastasisinvivoandenhancesefficacyofrADIationtherapyinamodelofcolorectalcarcinoma.
DSR6434isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 400.48 |
| Formula | C19H28N8O2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1059070-10-8 |
| PubChemID | 25071151 |
| InChIKey | SSZHESNDOMBSRV-UHFFFAOYSA-N |
| Smiles | O=C2N(CC3=CC=C(OCCN(C)C)N=C3)C1=NC(NCCCC)=NC(N)=C1N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 20.02 | 50 | |
| DMSO | 40.05 | 100 |
Thefollowingdataisbasedontheproductmolecularweight400.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.5mL | 12.49mL | 24.97mL |
| 5mM | 0.5mL | 2.5mL | 4.99mL |
| 10mM | 0.25mL | 1.25mL | 2.5mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |



