mSTINGagonist;selectiveformouseSTINGoverhumanSTING.InducesIFN-βandcytokineproductionfrombonemarrow-deriveddendriticcells.Causestumorregressionfollowingintratumoraladministrationinmousetumormodels.Inducesanadaptiveimmuneresponsetoreducesystemictumorgrowthandprovidesimmunologicalmemoryagainstautologoustumorre-challenge.Alsoantiviral.
M.Wt | 282.29 |
Formula | C17H14O4 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 117570-53-3 |
PubChemID | 123964 |
InChIKey | XGOYIMQSIKSOBS-UHFFFAOYSA-N |
Smiles | O=C1C2=CC=CC(CC(O)=O)=C2OC3=C1C=CC(C)=C3C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 5.65 | 20 | |
ethanol | 1.41 | 5mMwithsonication |
Thefollowingdataisbasedontheproductmolecularweight282.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.54mL | 17.71mL | 35.42mL |
5mM | 0.71mL | 3.54mL | 7.08mL |
10mM | 0.35mL | 1.77mL | 3.54mL |
50mM | 0.07mL | 0.35mL | 0.71mL |