Nuclearfactor(erythroid-derived)-like2(Nrf2)pathwayactivator;inducesupregulationofantioxidantgeneexpression.Displayscytoprotectiveeffectsinhumanspinalcordastrocytes,oligodendrocyteprecursorcellsandhippocampalneuronsfollowinghydrogenperoxidechallenge.Exertsneuroprotectiveeffectsinvivoinexperimentalautoimmuneencephalomyelitis.Primarymetabolite(MMF,Cat.No.4511)available.
M.Wt | 144.13 |
Formula | C6H8O4 |
Storage | StoreatRT |
Purity | ≥99% |
CASNumber | 624-49-7 |
PubChemID | 637568 |
InChIKey | LDCRTTXIJACKKU-ONEGZZNKSA-N |
Smiles | O=C(/C=C/C(OC)=O)OC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 14.41 | 100 | |
ethanol | 7.21 | 50 |
Thefollowingdataisbasedontheproductmolecularweight144.13.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 6.94mL | 34.69mL | 69.38mL |
5mM | 1.39mL | 6.94mL | 13.88mL |
10mM | 0.69mL | 3.47mL | 6.94mL |
50mM | 0.14mL | 0.69mL | 1.39mL |