Water-solubleanalogof17-AAG(Cat.No.1515)andgeldanamycin(Cat.No.1368).BindstheATPbindingsiteofHsp90andinhibitsitschaperoneactivity.Displaysmorepotentantitumoractivitythan17-AAG(meanGI50valuesare53and123nMfor17-DMAGand17-AAGrespectively).
SoldwiththepermissionoftheNIH,USPatent6,890,917
M.Wt | 653.21 |
Formula | C32H48N4O8.HCl |
Storage | Desiccateat-20°C |
Purity | ≥99%(HPLC) |
CASNumber | 467214-21-7 |
PubChemID | 9852573 |
InChIKey | DFSYBWLNYPEFJK-IHLRWNDRSA-N |
Smiles | O=C1C(NCCN(C)C)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 19.6 | 30 | |
ethanol | 6.53 | 10 |
Thefollowingdataisbasedontheproductmolecularweight653.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.53mL | 7.65mL | 15.31mL |
5mM | 0.31mL | 1.53mL | 3.06mL |
10mM | 0.15mL | 0.77mL | 1.53mL |
50mM | 0.03mL | 0.15mL | 0.31mL |