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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/17-DMAG hydrochloride/2610/1/1 mg
产品编号:2610/1
市  场 价:¥4500.00
场      地:美国(厂家直采)
产品分类: 蛋白类>天然蛋白>白蛋白>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$225.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/17-DMAG hydrochloride/2610/1/1 mg
商品介绍
Description:Water-solubleHsp90inhibitor
AlternativeNames:NSC707545
ChemicalName:17-Demethoxy-17-[[2-(dimethylamino)ethyl]amino]geldanamycinhydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Water-solubleanalogof17-AAG(Cat.No.1515)andgeldanamycin(Cat.No.1368).BindstheATPbindingsiteofHsp90andinhibitsitschaperoneactivity.Displaysmorepotentantitumoractivitythan17-AAG(meanGI50valuesare53and123nMfor17-DMAGand17-AAGrespectively).

LicensingInformation

SoldwiththepermissionoftheNIH,USPatent6,890,917

TechnicalData

M.Wt653.21
FormulaC32H48N4O8.HCl
StorageDesiccateat-20°C
Purity≥99%(HPLC)
CASNumber467214-21-7
PubChemID9852573
InChIKeyDFSYBWLNYPEFJK-IHLRWNDRSA-N
SmilesO=C1C(NCCN(C)C)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO19.630
ethanol6.5310

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight653.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.53mL7.65mL15.31mL
5mM0.31mL1.53mL3.06mL
10mM0.15mL0.77mL1.53mL
50mM0.03mL0.15mL0.31mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet