Freefattyacidreceptor1(FFA1/GPR40)antagonist.InhibitsFFA-inducedincreasesinintracellularCa2+levelsandsuppressespalmiticacidpotentiatedglucose-stimulatedinsulinsecretioninMin6pancreaticβcellsinvitro.Decreasesseruminsulinlevels,improvesinsulinsensitivityandreducesthenumberofapoptoticpancreaticβcellsinobesediabetic(db/db)rats.
DC260126isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 307.38 |
Formula | C16H18FNO2S |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 346692-04-4 |
PubChemID | 2843133 |
InChIKey | CNGHPXKWPGIDSK-UHFFFAOYSA-N |
Smiles | CCCCC(C=C2)=CC=C2NS(C1=CC=C(F)C=C1)(=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 30.74 | 100 | |
ethanol | 30.74 | 100 |
Thefollowingdataisbasedontheproductmolecularweight307.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.25mL | 16.27mL | 32.53mL |
5mM | 0.65mL | 3.25mL | 6.51mL |
10mM | 0.33mL | 1.63mL | 3.25mL |
50mM | 0.07mL | 0.33mL | 0.65mL |