Freefattyacidreceptor1(FFA1/GPR40)antagonist.InhibitsFFA-inducedincreasesinintracellularCa2+levelsandsuppressespalmiticacidpotentiatedglucose-stimulatedinsulinsecretioninMin6pancreaticβcellsinvitro.Decreasesseruminsulinlevels,improvesinsulinsensitivityandreducesthenumberofapoptoticpancreaticβcellsinobesediabetic(db/db)rats.
DC260126isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight307.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.