Immunosuppressant;inhibitsphosphataseactivityofcalcineurin(IC50=5nM).AlsoinhibitsformationandopeningofthemitochondrialpermeABIlitytransitionpore(MPTP).
CyclosporinAisalsoofferedaspartoftheTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 1202.63 |
Formula | C62H111N11O12 |
Storage | Desiccateat-20°C |
Purity | ≥99%(HPLC) |
CASNumber | 59865-13-3 |
PubChemID | 2909 |
InChIKey | PMATZTZNYRCHOR-UHFFFAOYSA-N |
Smiles | OC(C(CC=CC)C)C1C(=O)NC(C(=O)N(C)CC(N(C)C(CC(C)C)C(NC(C(=O)N(C)C(CC(C)C)C(NC(C)C(=O)NC(C)C(N(C)C(C(N(C)C(C(N(C)C(C(C)C)C(=O)N1C)=O)CC(C)C)=O)CC(C)C)=O)=O)C(C)C)=O)=O)CC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 120.26 | 100 | |
ethanol | 60.13 | 50 |
Thefollowingdataisbasedontheproductmolecularweight1202.63.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 0.83mL | 4.16mL | 8.32mL |
5mM | 0.17mL | 0.83mL | 1.66mL |
10mM | 0.08mL | 0.42mL | 0.83mL |
50mM | 0.02mL | 0.08mL | 0.17mL |