Nitrogenmustardalkylatingagentandprodrug.Phosphoramidemustard(activemetabolite)formsDNAcross-linksleADIngtocelldeath.Inhibitsaldehydedehydrogenase1(ALDH1)throughitsdegradationproductacrolein.Chemotherapeuticforthetreatmentofbreastcancer;regulatesBaxandBcl-2expressionwhenadmiNISTeredwithetoposide(Cat.No.1226)inbreastcancercelllines.
M.Wt | 261.09 |
Formula | C7H15Cl2N2O2P |
Storage | Storeat-20°C |
Purity | ≥99%(HPLC) |
CASNumber | 50-18-0 |
PubChemID | 2907 |
InChIKey | CMSMOCZEIVJLDB-UHFFFAOYSA-N |
Smiles | O=P1(N(CCCl)CCCl)OCCCN1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 26.11 | 100 | |
water | 26.11 | 100 |
Thefollowingdataisbasedontheproductmolecularweight261.09.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.83mL | 19.15mL | 38.3mL |
5mM | 0.77mL | 3.83mL | 7.66mL |
10mM | 0.38mL | 1.92mL | 3.83mL |
50mM | 0.08mL | 0.38mL | 0.77mL |