Description:InhibitorofHedgehog(Hh)signaling
ChemicalName:(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Inhibitorofhedgehog(Hh)signaling,likelyviadirectinhibitionofSmoothened,theaccessoryproteintotheputativeHhreceptorPatched.Anticancerandteratogenicinvivo.Depletesstem-likecancercellsinglioblastomaandblockstumorengraftment.Canalsobeusedtoinducedifferentiationofhumanembryonicstemcells(hESCs)intohormone-expressingendocrinecells.
TechnicalData
M.Wt | 411.63 |
Formula | C27H41NO2 |
Storage | Desiccateat-20°C |
Purity | ≥97%(HPLC) |
CASNumber | 4449-51-8 |
PubChemID | 442972 |
InChIKey | QASFUMOKHFSJGL-LAFRSMQTSA-N |
Smiles | O[C@H](C2)CC[C@@]1(C)C2=CC[C@]([C@@]([H])3CC[C@@]54O[C@@](C[C@H](C)CN6)([H])[C@]6([H])[C@H]5C)([H])[C@@]([H])1CC3=[C@@]4C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
---|
Solubility |
---|
ethanol | 2.06 | 5 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight411.63.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|
1mM | 2.43mL | 12.15mL | 24.29mL |
5mM | 0.49mL | 2.43mL | 4.86mL |
10mM | 0.24mL | 1.21mL | 2.43mL |
50mM | 0.05mL | 0.24mL | 0.49mL |
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
Selectanotherlanguage: