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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Cyclopamine/1623/1/1 mg
产品编号:1623/1
市  场 价:¥3700.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$185.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Cyclopamine/1623/1/1 mg
商品介绍
Description:InhibitorofHedgehog(Hh)signaling
ChemicalName:(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-3-ol
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Inhibitorofhedgehog(Hh)signaling,likelyviadirectinhibitionofSmoothened,theaccessoryproteintotheputativeHhreceptorPatched.Anticancerandteratogenicinvivo.Depletesstem-likecancercellsinglioblastomaandblockstumorengraftment.Canalsobeusedtoinducedifferentiationofhumanembryonicstemcells(hESCs)intohormone-expressingendocrinecells.

TechnicalData

M.Wt411.63
FormulaC27H41NO2
StorageDesiccateat-20°C
Purity≥97%(HPLC)
CASNumber4449-51-8
PubChemID442972
InChIKeyQASFUMOKHFSJGL-LAFRSMQTSA-N
SmilesO[C@H](C2)CC[C@@]1(C)C2=CC[C@]([C@@]([H])3CC[C@@]54O[C@@](C[C@H](C)CN6)([H])[C@]6([H])[C@H]5C)([H])[C@@]([H])1CC3=[C@@]4C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
ethanol2.065

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight411.63.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.43mL12.15mL24.29mL
5mM0.49mL2.43mL4.86mL
10mM0.24mL1.21mL2.43mL
50mM0.05mL0.24mL0.49mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet