ImidazoleantimycoticandcytochromeP450inhibitor.InhibitsCa2+-activatedK+current(IC50=3μM)andL-typeCa2+current;increasesthefiringrateofactionpotentials.Exhibitsantiproliferativeactivityinvitroandinvivo.AlsoaninverseagoNISTofthehumanconstitutiveandrostanereceptor(hCAR).
ClotrimazoleisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 344.84 |
Formula | C22H17ClN2 |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 23593-75-1 |
PubChemID | 2812 |
InChIKey | VNFPBHJOKIVQEB-UHFFFAOYSA-N |
Smiles | ClC1=CC=CC=C1C(C3=CC=CC=C3)(C4=CC=CC=C4)N2C=CN=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 25.86 | 75 | |
ethanol | 34.48 | 100 |
Thefollowingdataisbasedontheproductmolecularweight344.84.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.9mL | 14.5mL | 29mL |
5mM | 0.58mL | 2.9mL | 5.8mL |
10mM | 0.29mL | 1.45mL | 2.9mL |
50mM | 0.06mL | 0.29mL | 0.58mL |