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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Cladribine/5292/50/50 mg
产品编号:5292/50
市  场 价:¥7980.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$399.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Cladribine/5292/50/50 mg
商品介绍
Description:Deoxyadenosineanalog;pro-apoptotic
AlternativeNames:2-Chloro-2'-deoxyadenosine
ChemicalName:(2R,3S,5R)-5-(6-Amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxalan-3-ol
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Adenosinedeaminase(ADA)-resistantanalogofdeoxyadenosine.Exhibitsanti-leukemicactivity;Inhibitscellgrowthoflymphoidandmyeloidneoplasm(IC50=20-87nM).Pro-apoptotic;inducesDNAdouble-strandbreaks.Alsoinhibitsribonucleasereductase(IC50=0.11-0.28μM).Displaysactivityinvitroandinvivo.Orallybioavailable.

TechnicalData

M.Wt285.69
FormulaC10H12ClN5O3
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber4291-63-8
PubChemID20279
InChIKeyPTOAARAWEBMLNO-KVQBGUIXSA-N
SmilesOC[C@H]1O[C@@H](N2C=NC3=C2N=C(Cl)N=C3N)C[C@@H]1O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO28.57100
water1.435mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight285.69.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.5mL17.5mL35mL
5mM0.7mL3.5mL7mL
10mM0.35mL1.75mL3.5mL
50mM0.07mL0.35mL0.7mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet