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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Cinacalcet hydrochloride/6170/50/50 mg
产品编号:6170/50
市  场 价:¥7500.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$375.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Cinacalcet hydrochloride/6170/50/50 mg
商品介绍
Description:Calcium-sensingreceptor(CaSR)allostericagoNIST;alsoCYP2D2inhibitorandCa2+channelblocker;orallybioavailable
AlternativeNames:AMG073
ChemicalName:N-[(1R)-1-(1-Naphthyl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-aminehydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Calcium-sensingreceptor(CaSR)allostericagonist.ActivatesCaSRsignalingincellularproliferationandphosphatidylinositol(PI)hydrolysisassays.Reducesserumparathyroidhormonelevelsinrats.AlsopotentCYP2D2inhibitor(IC50=87nM)andL-typecalciumchannelblocker.Orallybioavailable.

TechnicalData

M.Wt393.87
FormulaC22H22F3N.HCl
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber364782-34-3
PubChemID156418
InChIKeyQANQWUQOEJZMLL-PKLMIRHRSA-N
SmilesC[C@H](C1=CC=CC2=C1C=CC=C2)NCCCC3=CC(C(F)(F)F)=CC=C3.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO39.39100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight393.87.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.54mL12.69mL25.39mL
5mM0.51mL2.54mL5.08mL
10mM0.25mL1.27mL2.54mL
50mM0.05mL0.25mL0.51mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet