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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Ciliobrevin A/4529/50/50 mg
产品编号:4529/50
市  场 价:¥14180.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$709.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Ciliobrevin A/4529/50/50 mg
商品介绍
Description:Hedgehog(Hh)pathwayantagoNIST,inhibitsciliogenesis;alsoinhibitsdynein
AlternativeNames:HPI-4
ChemicalName:2,4-Dichloro-α-(3,4-4-oxo-2(1H)-quinazolinylidene)-β-oxobenzenepropanenitrile
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Hedgehog(Hh)pathwayantagonist;blocksSonichedgehog(Shh)-inducedHhpathwayactivation(IC50=7μM)downstreamofSmo.Perturbsprimaryciliaformation;inhibitscytoplasmicAAA+ATPasedynein-dependentmicrotubuleglidingandATPaseactivity.

TechnicalData

M.Wt358.18
FormulaC17H9Cl2N3O2
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber302803-72-1
PubChemID6883982
InChIKeySESYPWCSIZUIAS-FOWTUZBSSA-N
SmilesO=C(C1=CC=CC=C1N2)N/C2=C(C(C3=C(Cl)C=C(Cl)C=C3)=O)C#N

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO35.82100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight358.18.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.79mL13.96mL27.92mL
5mM0.56mL2.79mL5.58mL
10mM0.28mL1.4mL2.79mL
50mM0.06mL0.28mL0.56mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet