Chaloneanalogthatdisplayanti-inflammatoryactivity.InhibitsNOandPGE2productionfromLPS-andIFN-γ-inducedRAWcellsandinhibitsTXB2productionviatheCOX-1andCOX-2pathways.InhibitsNF-κBactivationviainhibitionofIκBαdegradationandphosphorylation,IκBkinaseactivationandNF-κBnucleartranslocation.
M.Wt | 270.28 |
Formula | C16H14O4 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 19309-14-9 |
PubChemID | 641785 |
InChIKey | NYSZJNUIVUBQMM-BQYQJAHWSA-N |
Smiles | OC1=CC(O)=C(C(/C=C/C2=CC=CC=C2)=O)C(OC)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 27.03 | 100 | |
ethanol | 5.41 | 20 |
Thefollowingdataisbasedontheproductmolecularweight270.28.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.7mL | 18.5mL | 37mL |
5mM | 0.74mL | 3.7mL | 7.4mL |
10mM | 0.37mL | 1.85mL | 3.7mL |
50mM | 0.07mL | 0.37mL | 0.74mL |