Description:Proteinphosphatase1and2Ainhibitor
ChemicalName:N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S,9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazoly]butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-L-ribonamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Potentandselectivecell-permeableinhibitorofproteinphosphatase1(IC50=0.3-0.7nM)andproteinphosphatase2A(IC50=0.5-1nM).Displays>10,000,000-foldselectivityoverPP2BandPP2C.
TechnicalData
M.Wt | 1009.18 |
Formula | C50H81N4O15P |
Storage | Desiccateat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 101932-71-2 |
PubChemID | 3894 |
InChIKey | ULTTYPMRMMDONC-UHFFFAOYSA-N |
Smiles | O[C@H]1[C@H](C)[C@H](C/C=C/C3=COC([C@@H](C)CCNC([C@H]([C@H]([C@@H](N(C)C)COC)O)O)=O)=N3)O[C@]2([C@](C)(C)[C@@H](OP(O)(O)=O)[C@]([C@@H](OC)C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C(C)/C(C)=C/C=C/C(C)=CC#N)([H])O2)C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
---|
Solubility |
---|
DMSO | 50.46 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight1009.18.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|
1mM | 0.99mL | 4.95mL | 9.91mL |
5mM | 0.2mL | 0.99mL | 1.98mL |
10mM | 0.1mL | 0.5mL | 0.99mL |
50mM | 0.02mL | 0.1mL | 0.2mL |
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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