Potent,cell-permeableinhibitoroftheCa2+-dependentprotease,calpain.Preventscollagen-andthrombin-inducedplateletaggregation,probablybyblockingcalpaininducedphospholipaseCandthromboxanesynthaseactivation.PotentcathepsinLinhibitor.Recentlyshowntopreferentiallyinhibitasubsetofprotein-tyrosinephosphatases.
CalpeptinisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 362.47 |
Formula | C20H30N2O4 |
Storage | Desiccateat+4°C |
CASNumber | 117591-20-5 |
PubChemID | 73364 |
InChIKey | PGGUOGKHUUUWAF-ROUUACIJSA-N |
Smiles | O=C(OCC1=CC=CC=C1)N[C@H](C(N[C@H](C([H])=O)CCCC)=O)CC(C)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solubility | Solubleto100mMinDMSO |
Thefollowingdataisbasedontheproductmolecularweight362.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.76mL | 13.79mL | 27.59mL |
5mM | 0.55mL | 2.76mL | 5.52mL |
10mM | 0.28mL | 1.38mL | 2.76mL |
50mM | 0.06mL | 0.28mL | 0.55mL |