Calmodulinantagonist.Inhibitscalmodulin-dependentphosphodiesteraseandCa2+-transportingATPasewithIC50valuesof0.15and0.35μMrespectively.AlsocauseselevationofintracellularcalciuminHL-60cells,independentofcalmodulininhibition.
M.Wt | 687.7 |
Formula | C31H23Cl7N2O |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 57265-65-3 |
PubChemID | 644274 |
InChIKey | YGEIMSMISRCBFF-UHFFFAOYSA-M |
Smiles | [Cl-].ClC1=CC=C(C=C1)C(N1C=C[N+](CC(OCC2=CC=C(Cl)C=C2Cl)C2=CC=C(Cl)C=C2Cl)=C1)C1=CC=C(Cl)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 68.77 | 100 | |
ethanol | 68.77 | 100 |
Thefollowingdataisbasedontheproductmolecularweight687.7.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.45mL | 7.27mL | 14.54mL |
5mM | 0.29mL | 1.45mL | 2.91mL |
10mM | 0.15mL | 0.73mL | 1.45mL |
50mM | 0.03mL | 0.15mL | 0.29mL |